• An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache.
  NCI
  U.S. National Cancer Institute, 2021
• Primary hyperaldosteronism caused by an aldosterone-secreting adenoma.
  NICHD Pediatric Terminology
  U.S. National Cancer Institute, 2021
• Primary hyperaldosteronism caused by the excess production of ALDOSTERONE by an ADENOMA of the ZONA GLOMERULOSA or CONN ADENOMA.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025
• (conn's syndrome) Overproduction of aldosterone by an adrenal cortical adenoma, characterized typically by low potassium levels, underacidity of the body, muscular weakness, excess urination, excess thirst, and high blood pressure.
  CRISP Thesaurus
  National Institutes of Health, 2006
• (primary hyperaldosteronism) A form of hyperaldosteronism caused by a defect within the adrenal gland.
  Human Phenotype Ontology (HPO)
  The Human Phenotype Ontology Project, 2025
• Primary aldosteronism is aldosteronism caused by autonomous production of aldosterone by the adrenal cortex (due to hyperplasia, adenoma, or carcinoma). Symptoms and signs include episodic weakness, elevated blood pressure, and hypokalemia. Diagnosis includes measurement of plasma aldosterone levels and plasma renin activity. Treatment...
  Merck Manuals
  Merck & Co., Inc., 2025
• Although initially considered a rarity, primary aldosteronism now is considered one of the more common causes of secondary hypertension (HTN). Litynski reported the first cases, but Conn was the first to well characterize the disorder, in 1956.
  Medscape
  WebMD, 2025
• Primary aldosteronism (al-DOS-tuh-ro-niz-um) is a hormonal disorder that leads to high blood pressure. It occurs when your adrenal glands produce too much of a hormone called aldosterone.
  Mayo Clinic
  Mayo Foundation for Medical Education and Research, 2025
• Primary hyperaldosteronism is a disorder caused by excess production of the hormone aldosterone by the adrenal glands. The main symptom of primary hyperaldosteronism is high blood pressure (hypertension), but other symptoms may include headaches, weakness, swelling (edema), and muscle spasms (tetany). The cause of primary...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• In primary aldosteronism (PA), aldosterone production exceeds the body's requirements and is relatively autonomous with regard to its normal chronic regulator, the renin-angiotensin II system. This results in excessive sodium reabsorption via amiloride-sensitive epithelial sodium channels within the distal nephron, leading to...
  Epocrates
  Athenahealth, Inc., 2019