Genetic Function
RNA interference
Subclass of:
Gene Silencing
Definitions related to rna interference:
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A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Gene silencing phenomenon or technique whereby specific double stranded RNAs trigger degradation of the homologous mRNA; the specific double stranded RNAs are processed into small interfering RNAs which serve as a guide for cleavage of the homologous mRNA in the RNA induced silencing complex.CRISP ThesaurusNational Institutes of Health, 2006
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Sequence-specific posttranscriptional gene silencing. It is mediated by 21- and 22-nucleotide small interfering RNAs (siRNAs) generated by ribonuclease III cleavage from longer dsRNAs.NCI ThesaurusU.S. National Cancer Institute, 2021
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The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.Gene Ontology DictionaryGene Ontology Consortium, 2021
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(posttranscriptional gene silencing) The inactivation of gene expression by a posttranscriptional mechanism.Gene Ontology DictionaryGene Ontology Consortium, 2021
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RNA interference (RNAi), regulatory system occurring within eukaryotic cells (cells with a clearly defined nucleus) that controls the activity of genes. RNAi functions specifically to silence, or deactivate, genes. The ability of interfering RNA to silence genes was discovered in the 1990s by...Encyclopedia Britannica, Inc., 2020
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