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Related terms:
fatty liver
hepatic encephalopathy
kernicterus
Disease or Syndrome
Reye's syndrome Audio
Reye's syn·drome [ rahyz, reyz ]
Subclass of:
Brain Diseases, Metabolic; Fatty Liver
Also called:
Reye's Syndrome
Definitions related to reye syndrome:
  • A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A rare disease that damages the brain and liver and causes death if not treated. It occurs most often in children younger than 15 years who have had a fever-causing virus, such as chickenpox or flu. Taking aspirin during a viral illness may increase the risk of Reye syndrome.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A rare, systemic disease characterized by persistent vomiting with confusion, lethargy, disorientation, hyperreflexia, hyperventilation, and tachycardia, with rapid progression to seizures, non-inflammatory encephalopathy, coma and death. It typically develops between 12 hours and 3 weeks after recovery from a viral illness, such as upper respiratory tract infection or gastroenteritis. Hepatomegaly, acute hepatic steatosis, fatty liver degeneration and multiple laboratory abnormalities are associated.
    OrphaNet
    INSERM, 2021
  • An acute and potentially fatal metabolic condition characterized by cerebral edema, fatty liver, and hypoglycemia. It occurs primarily in children, and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use.
    NICHD Pediatric Terminology
    U.S. National Cancer Institute, 2021
  • An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use.
    NCI
    U.S. National Cancer Institute, 2021
  • Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include: Nausea and vomiting; Listlessness; Personality change - such as irritability, combativeness or confusion; Delirium; Convulsions; Loss of consciousness. If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke
    MedlinePlus
    U.S. National Library of Medicine, 2025
  • (reye's syndrome) Rare, acute, sometimes fatal disease of childhood, most often occurring as a sequel of varicella or a viral upper respiratory infection of childhood; marked by recurrent vomiting and elevated serum transaminase levels with distinctive changes in the liver and other viscera; an encephalopathic phase with acute brain swelling disturbances of consciousness and seizures may follow.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Reye syndrome is a rare form of acute encephalopathy and fatty infiltration of the liver that tends to occur after some acute viral infections, particularly when salicylates are used. Diagnosis is clinical. Treatment is supportive.
    Merck Manuals
    Merck & Co., Inc., 2025
  • Reye syndrome is characterized by acute noninflammatory encephalopathy and fatty degenerative liver failure. The syndrome was first described in 1963 in Australia by RDK Reye and described a few months later in the United States by GM Johnson.
    Medscape
    WebMD, 2025
  • Reye's (Reye) syndrome is a rare but serious condition that causes swelling in the liver and brain. Reye's syndrome most often affects children and teenagers recovering from a viral infection, most commonly the flu or chickenpox.
    Mayo Clinic
    Mayo Foundation for Medical Education and Research, 2025
  • Reye syndrome is an illness that meets all the following criteria: an acute, noninflammatory encephalopathy with either sterile CSF containing <9 WBC/mL or cerebral edema without inflammatory cell infiltrate; hepatic dysfunction documented by either a threefold elevation of serum transaminases and/or serum ammonia, or liver biopsy...
    Epocrates
    Athenahealth, Inc., 2019
  • Reye syndrome, acute neurologic disease that develops primarily in children following influenza, chicken pox, or other viral infections. It may result in accumulation of fat in the liver and swelling of the brain. The disease was first reported by the Australian pathologist R.D.K. Reye in 1963....
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.

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