Disease or Syndrome
Stevens-Johnson syndrome
Subclass of:
Erythema Multiforme;
Drug Eruptions;
Stomatitis
Definitions related to stevens-johnson syndrome:
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A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma).NCI ThesaurusU.S. National Cancer Institute, 2021
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(stevens johnson syndrome) Drug or microbial induced exanthem characterized by papular or target-like lesions that involve less than 30% of the skin surface and at least two mucous membranes associated with systemic symptoms and may result in variable areas of skin necrosis.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.Common Terminology Criteria for Adverse EventsU.S. National Institutes of Health, 2021
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Stevens-Johnson syndrome (SJS) is an immune-complex�mediated hypersensitivity complex that typically involves the skin and the mucous membranes. While minor presentations may occur, significant involvement of oral, nasal, eye, vaginal, urethral, gastrointestinal, and lower respiratory tract mucous membranes may develop in the course of...WebMD, 2019
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Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes. It's usually a reaction to medication that starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Then the top layer of affected skin dies, sheds and begins to heal after several days.Mayo Foundation for Medical Education and Research
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Stevens-Johnson syndrome (SJS) is a severe skin detachment with mucocutaneous complications. It is an immune reaction to foreign antigens. SJS is a more severe form of erythema multiforme major and a less severe manifestation of toxic epidermal necrolysis (TEN). Classification is dependent on the percentage of skin involvement: SJS has...Athenahealth, Inc., 2019
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