Pharmacologic Substance
abatacept
Brand Names:
Orencia
Effect:
T Lymphocyte Costimulation Activity Blockade
May Treat:
Arthritis, Juvenile;
Arthritis, Psoriatic;
Arthritis, Rheumatoid
More Information:
Definitions related to abatacept:
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A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.NCI ThesaurusU.S. National Cancer Institute, 2021
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