Pharmacologic Substance
abiraterone acetate Audio
[ a-bih-ra-teh-rone a-seh-tayt ]
May Treat:
Prostatic Neoplasms, Castration-Resistant
More Information:
ChemID; DailyMed; PDR
Definitions related to abiraterone acetate:
  • A substance being studied in the treatment of prostate cancer and breast cancer. It blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of cancer cells that need androgens to grow. It is a type of anti-androgen.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.
    NCI
    U.S. National Cancer Institute, 2021
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