Pathologic Function
acantholysis
a·can·thol·y·sis
Subclass of:
Skin Diseases, Vesiculobullous; Pathologic Processes
Definitions related to acantholysis:
  • Atrophy of the stratum spinosum layer of the epidermis due to disruption of the intercellular attachments between keratinocytes.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris and DARIER DISEASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.