Organic Chemical
acridine Audio
ac·ri·dine [ ak-ri-deen, -din ]
Definitions related to acridine:
  • A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.
    NCI
    U.S. National Cancer Institute, 2021
  • Heterocyclic three ring compound.
    CRISP Thesaurus
    National Institutes of Health, 2006
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