Neoplastic Process
acute promyelocytic leukemia
[ uh-kyoot proh-my-eh-loh-sih-tik loo-kee-mee-uh ]
Subclass of:
Leukemia, Myelocytic, Acute
Definitions related to acute promyelocytic leukemia:
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(promyelocytic leukemia) An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A type of acute myeloid leukemia in which abnormal promyelocytes predominate.Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
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(leukemia, promyelocytic, acute) An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(acute promyelocytic leukemia with pml-rara) An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the PML-RARA fusion. There are two variants: the typical and microgranular variant. This AML is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis. (WHO)NCI ThesaurusU.S. National Cancer Institute, 2021
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(acute promyelocytic leukemia with t(15;17)(q22;q12); pml-rara) Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), and it is treated differently than other types of AML because of its marked sensitivity to differentiating effects of all trans-retinoic acid. APL is characterized by a severe coagulopathy which may be present at diagnosis. APL occurs in 7 % of children with AML.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Acute promyelocytic leukemia (APL) is a unique subtype of the acute leukemias. It has distinct cytogenetics, clinical features, and biologic characteristics.WebMD, 2019
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Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells (promyelocytes) in the blood and bone marrow. This build up of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body. The signs and symptoms of APL include...National Center for Advancing Translational Sciences
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