Pharmacologic Substance
afimoxifene
Definitions related to afimoxifene:
  • A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.
    NCI
    U.S. National Cancer Institute, 2021
  • (4-hydroxytamoxifen) A form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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