• A condition in which a person is unable to relax and be still. The person may be very tense and irritable, and become easily annoyed by small things. He or she may be eager to have an argument, and be unwilling to work with caregivers to make the situation better.
  NCI Dictionary of Cancer Terms
  U.S. National Cancer Institute, 2021
• A state of excessive motor activity that is associated with mental distress or a feeling of substantial unease or inner tension. Distinguished from restlessness by the increased level of emotional distress and negative intensity of the experience. Agitation has a significant level of physical activity that is typically threatening to the self or others.
  Human Phenotype Ontology (HPO)
  The Human Phenotype Ontology Project, 2025
• A state of restlessness associated with unpleasant feelings of irritability and tension. Causes include pain, stress, fever, alcohol and nicotine withdrawal, cocaine and hallucinogenic drugs use, depression, bipolar disorders, and schizophrenia.
  NCI
  U.S. National Cancer Institute, 2021
• Irritability associated with physical and psychological restlessness.
  NICHD Pediatric Terminology
  U.S. National Cancer Institute, 2021
• Severe anxiety associated with motor restlessness.
  Sadock's Comprehensive Glossary of Psychiatry and Psychology
  BJ Sadock Titles Press, 2012
• A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.
  Common Terminology Criteria for Adverse Events
  U.S. National Institutes of Health, 2021