Pharmacologic Substance
alanosine
[ uh-lan-oh-seen ]
Definitions related to alanosine:
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A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways.NCI ThesaurusU.S. National Cancer Institute, 2021
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