Enzyme
alteplase
Brand Names:
Activase
Effect:
Increased Thrombolysis
May Treat:
Arterial Occlusive Diseases;
Intracranial Embolism and Thrombosis;
Myocardial Infarction;
Pulmonary Embolism;
Stroke
More Information:
Definitions related to alteplase:
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A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.NCI ThesaurusU.S. National Cancer Institute, 2021
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(tissue plasminogen activator) A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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