Pharmacologic Substance
altretamine Audio
[ al-treh-tuh-meen ]
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Ovarian Neoplasms
Definitions related to altretamine:
  • A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anticancer drug that belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.