Pharmacologic Substance
aminoglutethimide
[ uh-mee-noh-gloo-teth-uh-mahyd, am-uh-noh- ]
Effect:
Decreased Glucocorticoid Secretion; Decreased Mineralocorticoid Secretion
May Treat:
Breast Neoplasms;
Cushing Syndrome;
Neoplasms, Hormone-Dependent;
Prostatic Neoplasms
Definitions related to aminoglutethimide:
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A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.NCI ThesaurusU.S. National Cancer Institute, 2021
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An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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USP lists as an antineoplastic and an "adrenocortical suppressant."CRISP ThesaurusNational Institutes of Health, 2006
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