Pharmacologic Substance
amonafide
[ ay-moh-nah-fide ]
Definitions related to amonafide:
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A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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