Pharmacologic Substance
amsilarotene
Definitions related to amsilarotene:
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A retinobenzoic acid with potential antineoplastic activity. Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called synthetic retinoids and angiogenesis inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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