Pharmacologic Substance
anakinra
[ a-nuh-kin-ruh ]
Brand Names:
Kineret
Effect:
Bone Resorption Inhibition; Decreased Immunologically Active Molecule Activity
May Treat:
Arthritis, Rheumatoid;
Cryopyrin-Associated Periodic Syndromes
More Information:
Definitions related to anakinra:
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A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic form of native human IL-1Ra that has an additional methionine residue at its amino terminus.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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