Pharmacologic Substance
anastrozole
an·as·tro·zole [ an-as-troh-zole ]
Brand Names:
Arimidex
Effect:
Decreased Ovarian Estrogen Secretion
May Treat:
Breast Neoplasms
More Information:
Definitions related to anastrozole:
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A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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