Biologically Active Substance
aprotinin
Effect:
Hemostasis Alteration
May Prevent:
Blood Loss, Surgical
May Treat:
Hemorrhage
More Information:
Definitions related to aprotinin:
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A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis.NCI ThesaurusU.S. National Cancer Institute, 2021
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A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Single-chain polypeptide inhibitor of proteolytic enzymes including chymotrypsin, kallikrein, plasmin, and trypsin; used in the treatment of hemorrhage associated with raised plasma concentrations of plasmin; also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with extracorporeal circulation.CRISP ThesaurusNational Institutes of Health, 2006
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