Enzyme
aromatase
a·ro·ma·tase
Definitions related to aromatase:
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A p450-like enzyme, Aromatase catalyzes, with an NADPH-linked reductase, the oxidative aromatization of androgens to estrogens. Expressed in gonads, palcenta and brain, Aromatase and NADPH-cytochrome P450 reductase (reductase) are both highly conserved, essential components of the enzyme complex and essential for reproductive development and fertility.NCI ThesaurusU.S. National Cancer Institute, 2021
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An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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NonEC; cytochrome P450-like enzyme which, with an NADPH-linked reductase, catalyzes the oxidative aromatization of androgens to estrogens in the placenta, ovary, and testis, and at lower levels throughout the body.CRISP ThesaurusNational Institutes of Health, 2006
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