Enzyme
aromatase Audio
a·ro·ma·tase
Definitions related to aromatase:
  • Aromatase (503 aa, ~58 kDa) is encoded by the human CYP19A1 gene. This protein is involved in the conversion of androgens to estrogens.
    NCI
    U.S. National Cancer Institute, 2021
  • An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • NonEC; cytochrome P450-like enzyme which, with an NADPH-linked reductase, catalyzes the oxidative aromatization of androgens to estrogens in the placenta, ovary, and testis, and at lower levels throughout the body.
    CRISP Thesaurus
    National Institutes of Health, 2006
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