Cell Function
axon guidance
ax·on guid·ance [ ak-son gahyd-ns ]
Subclass of:
Neuronal Outgrowth
Definitions related to axon guidance:
  • Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
    Kyoto Encyclopedia of Genes and Genomes
    Kanehisa Laboratories, 2021
  • The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
  • The mechanism by which a neuronal process outgrows toward a target led by the GROWTH CONE. Local guidance cues are provided by cell surface proteins that act on the growing axon.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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