Pharmacologic Substance
baclofen
[ bak-loh-fen ]
Brand Names:
Gablofen; Lioresal; Ozobax
Effect:
Central Nervous System Depression; Decreased Organized Electrical Activity; Decreased Striated Muscle Contraction; Increased Spinal Cord GABA Activity
May Treat:
Cerebral Palsy;
Hiccup;
Huntington Disease;
Multiple Sclerosis;
Muscle Spasticity;
Myelitis, Transverse;
Pain, Intractable;
Spinal Cord Injuries;
Spinal Cord Ischemia;
Spinal Cord Neoplasms;
Spondylolysis;
Trigeminal Neuralgia;
Urinary Bladder, Neurogenic
More Information:
Definitions related to baclofen:
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A drug that is used to treat certain types of muscle spasms and is being studied in the treatment of liver cancer. Baclofen relaxes muscles by blocking certain nerve receptors in the spinal cord. It is a type of antispasmodic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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