Immunologic Factor
becaplermin
Brand Names:
Regranex
Effect:
Increased Epithelial Proliferation
May Treat:
Diabetic Neuropathies
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to becaplermin:
  • A recombinant human platelet-derived growth factor B-chain dimer used to promote WOUND HEALING by stimulating PHYSIOLOGIC ANGIOGENESIS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • (platelet-derived growth factor-bb) A disulfide-linked homodimeric protein complex comprised of 2 platelet-derived growth factor subunit B proteins. This dimeric growth factor binds to a homodimeric receptor comprised of two platelet-derived growth factor receptor beta proteins. Ligand binding activates the intrinsic tyrosine-protein kinase activity of the receptor complex and initiates signal transduction pathways.
    NCI
    U.S. National Cancer Institute, 2021
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