Pharmacologic Substance
bexarotene Audio
[ bek-sayr-uh-teen ]
Brand Names:
Targretin
Effect:
Cellular Growth Phase Arrest; Decreased Transcription to RNA
May Treat:
Lymphoma, T-Cell, Cutaneous
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to bexarotene:
  • A drug used to treat skin problems caused by cutaneous T-cell lymphoma that have not gotten better after other treatment. It is also being studied in the treatment of other types of cancer. Bexarotene is a type of retinoid.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A rexinoid (an RXR-binding ligand), tetrahydronaphthalene derivative and RETINOID X RECEPTOR antagonist that is used in the treatment of CUTANEOUS T-CELL LYMPHOMA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.