Neoplastic Process
blast phase
blast phase
Subclass of:
Neoplastic Cell Transformation
Definitions related to blast phase:
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(blast crisis) A phase of chronic myelogenous leukemia in which 20% or more of the cells in the blood or bone marrow are blast cells (immature blood cells). When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(blast phase chronic myelogenous leukemia, bcr-abl1 positive) An advanced phase of chronic myelogenous leukemia. It is characterized by: 1. the presence of blasts in the peripheral blood or bone marrow that are at least 20% of the peripheral blood white cells or of the nucleated cells in the bone marrow respectively, or 2. an extramedullary proliferation of blasts, and/or 3. when there are large aggregates and clusters of blasts in the bone marrow biopsy specimen (adapted from WHO, 2001).NCI ThesaurusU.S. National Cancer Institute, 2021
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Blast crisis refers to the transformation of chronic myelogenous leukemia (CML) from the chronic or accelerated phase to blast phase. This is characterized by blast cells (?20% by WHO criteria; ?30% by MD Anderson Cancer Center and the International Bone Marrow Transplant Registry criteria) in the peripheral blood smear or the bone...Athenahealth, Inc., 2019
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