Pharmacologic Substance
busulfan Audio
[ byoo-suhl-fuhn ]
Brand Names:
Busulfex; Myleran
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Polycythemia Vera; Primary Myelofibrosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to busulfan:
  • A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Alkylating agent having a selective immunosuppressive effect on bone marrow; has been used in the palliative treatment of chronic myeloid leukemia.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An anticancer drug that belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.