Pharmacologic Substance
carbazilquinone
Subclass of:
Benzoquinones; Aziridines
Definitions related to carbazilquinone:
  • (carboquone) An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in carboquone becomes activated upon reduction of quinone to the hydroquinone form. This eventually results in the alkylation and crosslinking of DNA, thereby inhibiting DNA replication followed by an induction of apoptosis. In addition, reactive oxygen species may form during redox cycling which may contribute to this agent's cytotoxic activity.
    NCI
    U.S. National Cancer Institute, 2021
  • An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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