Pharmacologic Substance
carbidopa
Brand Names:
Duopa; Lodosyn; Rytary; Sinemet; Stalevo
Effect:
Increased Central Nervous System Dopamine Activity
May Treat:
Parkinson Disease
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to carbidopa:
  • A hydrazine derivative of dopa. Carbidopa is a peripheral dopa decarboxylase inhibitor that is used as an adjunct to levodopa administration to prevent peripheral biosynthesis of levodopa to dopamine, thereby reducing peripheral side effects. Carbidopa does not penetrate the blood brain barrier so that levodopa, after it reaches the brain, can be metabolized to dopamine by dopa decarboxylase where it exerts its effect on dopamine receptors.
    NCI
    U.S. National Cancer Institute, 2021
  • An inhibitor of DOPA DECARBOXYLASE that prevents conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no anti-parkinson activity by itself.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.