Pharmacologic Substance
carbidopa
Brand Names:
Duopa; Lodosyn; Rytary; Sinemet; Stalevo
Effect:
Increased Central Nervous System Dopamine Activity
May Treat:
Parkinson Disease
More Information:
Definitions related to carbidopa:
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A hydrazine derivative of dopa. Carbidopa is a peripheral dopa decarboxylase inhibitor that is used as an adjunct to levodopa administration to prevent peripheral biosynthesis of levodopa to dopamine, thereby reducing peripheral side effects. Carbidopa does not penetrate the blood brain barrier so that levodopa, after it reaches the brain, can be metabolized to dopamine by dopa decarboxylase where it exerts its effect on dopamine receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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An inhibitor of DOPA DECARBOXYLASE that prevents conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no anti-parkinson activity by itself.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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