Pharmacologic Substance
carboplatin Audio
[ kar-boh-pla-tin ]
Brand Names:
Paraplatin
Effect:
Decreased DNA Integrity
May Treat:
Bone Marrow Diseases; Breast Neoplasms; Central Nervous System Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Lung Neoplasms; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Ovarian Neoplasms; Urinary Bladder Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to carboplatin:
  • A drug that is used to treat advanced ovarian cancer that has never been treated or symptoms of ovarian cancer that has come back after treatment with other anticancer drugs. It is also used with other drugs to treat advanced, metastatic, or recurrent non-small cell lung cancer and is being studied in the treatment of other types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An organoplatinum compound that possesses antineoplastic activity.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Organoplatinum compound with antineoplastic activity.
    CRISP Thesaurus
    National Institutes of Health, 2006
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.