Pharmacologic Substance
carboprost
Brand Names:
Hemabate
Effect:
Increased GI Smooth Muscle Tone; Increased Prostaglandin Activity; Increased Uterine Smooth Muscle Contraction or Tone
May Treat:
Abortion, Incomplete;
Cystitis;
Fetal Death;
Postpartum Hemorrhage
More Information:
Definitions related to carboprost:
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A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.NCI ThesaurusU.S. National Cancer Institute, 2021
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