Molecular Function
caspase activation
Definitions related to caspase activation:
  • Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • (activation of cysteine-type endopeptidase activity involved in apoptotic process) Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
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