Antibiotic
cefazolin
Effect:
Decreased Cell Wall Synthesis & Repair
May Prevent:
Endocarditis, Bacterial; Surgical Wound Infection
May Treat:
Bites, Human; Endocarditis, Bacterial; Escherichia coli Infections; Klebsiella Infections; Pneumonia, Bacterial; Proteus Infections; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcal Infections; Streptococcal Infections; Urinary Tract Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to cefazolin:
  • A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
    NCI
    U.S. National Cancer Institute, 2021
  • A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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