Antibiotic
ceftazidime
Brand Names:
Avycaz; Fortaz; Tazicef
Effect:
Decreased Cell Wall Synthesis & Repair
May Treat:
Acinetobacter Infections;
Bone Diseases, Infectious;
Escherichia coli Infections;
Fever;
Haemophilus Infections;
Klebsiella Infections;
Meningitis, Bacterial;
Neutropenia;
Pneumonia, Bacterial;
Proteus Infections;
Pseudomonas Infections;
Sepsis;
Serratia Infections;
Skin Diseases, Bacterial;
Soft Tissue Infections;
Staphylococcal Infections;
Streptococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to ceftazidime:
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A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).NCI ThesaurusU.S. National Cancer Institute, 2021
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Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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