Pharmacologic Substance
chlorothiazide Audio
chlo·ro·thi·a·zide [ klawr-uh-thahy-uh-zahyd, klohr- ]
Brand Names:
Diuril
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Distal Tubule Cl- Excretion; Increased Distal Tubule H+ Excretion; Increased Distal Tubule HCO3- Excretion; Increased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion; Increased Diuresis
May Treat:
Edema; Glomerulonephritis; Heart Failure; Hypertension; Liver Cirrhosis; Nephrotic Syndrome; Renal Insufficiency
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to chlorothiazide:
  • A short-acting, benzothiadiazinesulfonamide derivative and prototypical thiazide diuretic. Chlorothiazide is excreted unchanged by the kidneys.
    NCI
    U.S. National Cancer Institute, 2021
  • A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Thiazide diuretic used to treat hypertension.
    CRISP Thesaurus
    National Institutes of Health, 2006
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