Indicator, Reagent, or Diagnostic Aid
clofazimine
Effect:
Cellular Synthetic Activity Alteration
May Treat:
Leprosy, Borderline; Leprosy, Lepromatous; Mycobacterium avium-intracellulare Infection; Pyoderma Gangrenosum
Definitions related to clofazimine:
  • A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A phenazine dye with anti-mycobacterial and anti-inflammatory activities. The exact mechanism through which clofazimine exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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