Pharmacologic Substance
clofibrate
[ kloh-fahy-breyt, -fib-reyt ]
Effect:
Decreased Lipolysis
May Prevent:
Coronary Artery Disease
May Treat:
Coronary Artery Disease; Hypercholesterolemia; Hyperlipoproteinemias; Hypertriglyceridemia
Definitions related to clofibrate:
  • A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols.
    NCI
    U.S. National Cancer Institute, 2021
  • Fibric acid derivative used in the treatment of hyperlipoproteinemia and hypertriglyceridemia.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.