Pharmacologic Substance
clonidine
[ klon-i-deen, kloh-ni- ]
Brand Names:
Catapres; Clorpres; Duraclon; Kapvay
Effect:
Analgesia; Decreased Blood Pressure; Negative Chronotropy; Neurotransmitter & Neuromuscular Transmitter Activity Alteration; Renal Arterial Vasodilation; Systemic Arterial Vasodilation
May Treat:
Alcohol-Induced Disorders, Nervous System;
Attention Deficit Disorder with Hyperactivity;
Diarrhea;
Dysmenorrhea;
Glaucoma;
Hot Flashes;
Hypertension;
Muscle Spasticity;
Pain, Intractable;
Sialorrhea;
Substance Withdrawal Syndrome;
Tourette Syndrome
More Information:
Definitions related to clonidine:
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Alpha-2 adrenergic agonist that crosses the blood-brain barrier; acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate; also acts peripherally.CRISP ThesaurusNational Institutes of Health, 2006
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An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.NCI ThesaurusU.S. National Cancer Institute, 2021
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An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.