Pharmacologic Substance
clonidine hydrochloride Audio
[ kloh-nih-deen hy-droh-klor-ide ]
Effect:
Analgesia; Decreased Blood Pressure; Decreased Sympathetic Organized Electrical Activity; Negative Chronotropy; Neurotransmitter & Neuromuscular Transmitter Activity Alteration; Renal Arterial Vasodilation; Systemic Arterial Vasodilation
May Treat:
Alcohol-Induced Disorders, Nervous System; Attention Deficit Disorder with Hyperactivity; Diarrhea; Dysmenorrhea; Glaucoma; Hot Flashes; Hypertension; Muscle Spasticity; Opioid-Related Disorders; Pain, Intractable; Sialorrhea; Substance Withdrawal Syndrome; Tourette Syndrome
More Information:
DailyMed; PubChem
Definitions related to clonidine hydrochloride:
  • A drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Catapres is a type of antihypertensive agent and a type of alpha-adrenergic agonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt form of clonidine, an imidazoline derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity. Clonidine hydrochloride binds to and stimulates central alpha-2 adrenergic receptors, thereby decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow, leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.