Pharmacologic Substance
cyclosporine
cy·clo·spo·rine [ sahy-kluh-spawr-een, -in, -spohr-, sik-luh- ]
Brand Names:
Atopica; Cequa; Cyclavance; Gengraf; Neoral; Optimmune; Restasis; Sandimmune
Effect:
Decreased Cytokine Activity; Decreased Cytokine Production; Decreased T Lymphocyte Production
May Prevent:
Graft vs Host Disease
May Treat:
Arthritis, Rheumatoid;
Glomerulosclerosis, Focal Segmental;
Lupus Erythematosus, Systemic;
Myasthenia Gravis;
Psoriasis
More Information:
Definitions related to cyclosporine:
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11-residue cyclic peptide produced by certain fungi which has antifungal and T cell specific immunosuppressive properties.CRISP ThesaurusNational Institutes of Health, 2006
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A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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