Pharmacologic Substance
cytarabine liposome
Effect:
Decreased DNA Integrity; Decreased RNA Integrity; Increased Cellular Death
May Treat:
Leukemia;
Lymphoma;
Meningeal Neoplasms
Definitions related to cytarabine liposome:
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A form of the anticancer drug cytarabine that is contained inside very tiny, fat-like particles. It may have fewer side effects and work better than cytarabine. It is used to treat lymphoma that has spread to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. It is a type of antimetabolite.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(liposomal cytarabine) A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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