Pharmacologic Substance
cytarabine liposome
Effect:
Decreased DNA Integrity; Decreased RNA Integrity; Increased Cellular Death
May Treat:
Leukemia; Lymphoma; Meningeal Neoplasms
Definitions related to cytarabine liposome:
  • A form of the anticancer drug cytarabine that is contained inside very tiny, fat-like particles. It may have fewer side effects and work better than cytarabine. It is used to treat lymphoma that has spread to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. It is a type of antimetabolite.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (liposomal cytarabine) A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.