Pharmacologic Substance
debrisoquin
Definitions related to debrisoquin:
  • 3,4-dihydro-2(H)-isoquinolinecarboxamidine (sulfate); oxidative metabolism of this drug is used to assay and model drug metabolism in general, especially genetic, ethnic, and individual pharmacokinetic differences.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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