Pharmacologic Substance
decitabine
[ deh-sih-tuh-been ]
Brand Names:
Dacogen; Inqovi
Effect:
Decreased DNA Integrity; Increased Cellular Death
May Treat:
Myelodysplastic Syndromes
More Information:
Definitions related to decitabine:
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A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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