Pharmacologic Substance
decitabine Audio
[ deh-sih-tuh-been ]
Brand Names:
Dacogen; Inqovi
Effect:
Decreased DNA Integrity; Increased Cellular Death
May Treat:
Myelodysplastic Syndromes
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to decitabine:
  • A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.