Pharmacologic Substance
deferasirox
[ deh-fer-a-ser-ox ]
Brand Names:
Exjade; Jadenu
May Treat:
Iron Overload
More Information:
Definitions related to deferasirox:
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A drug used to treat too much iron in the blood caused by blood transfusions. It is being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells) and other conditions. Deferasirox binds to extra iron in the blood. The drug and the iron are passed from the body in urine. It is a type of chelating agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.NCI ThesaurusU.S. National Cancer Institute, 2021
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A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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