Indicator, Reagent, or Diagnostic Aid
deferoxamine
[ deh-feh-rok-suh-meen ]
Brand Names:
Desferal
Effect:
Unknown Physiological Effect
May Prevent:
Iron Overload; Kidney Failure, Chronic
May Treat:
Bone Diseases;
Corneal Diseases;
Hemochromatosis
More Information:
Definitions related to deferoxamine:
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An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Natural product isolated from Streptomyces pilosus; it forms iron complexes and is used as a chelating agent, particularly in the mesylate form.CRISP ThesaurusNational Institutes of Health, 2006
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