Indicator, Reagent, or Diagnostic Aid
deferoxamine Audio
[ deh-feh-rok-suh-meen ]
Brand Names:
Desferal
Effect:
Unknown Physiological Effect
May Prevent:
Iron Overload; Kidney Failure, Chronic
May Treat:
Bone Diseases; Corneal Diseases; Hemochromatosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to deferoxamine:
  • An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Natural product isolated from Streptomyces pilosus; it forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.