Pharmacologic Substance
deoxyglucose
Subclass of:
Deoxy Sugars
Definitions related to deoxyglucose:
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2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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2-Deoxy-D-arabino-hexose; antimetabolite of glucose with antiviral activity.CRISP ThesaurusNational Institutes of Health, 2006
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(2-deoxy-d-glucose) A non-metabolizable glucose analog in which the hydroxyl group at position 2 of glucose is replaced by hydrogen, with potential glycolysis inhibiting and antineoplastic activities. Although the exact mechanism of action has yet to be fully elucidated, upon administration of 2-deoxy-D-glucose (2-DG), this agent competes with glucose for uptake by proliferating cells, such as tumor cells. 2-DG inhibits the first step of glycolysis and therefore prevents cellular energy production, which may result in decreased tumor cell proliferation.NCI ThesaurusU.S. National Cancer Institute, 2021
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