Genetic Function
depurination
Definitions related to depurination:
  • Depurination involves cleavage of the N-glycosidic link between a purine base and the remaining deoxyribose portion of the effected nucleotide in DNA, leading to loss of the purine base while leaving the DNA backbone intact. Depurination must be enzymically repaired to ensure genetic stability; transversion mutations result from purine loss.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.