Genetic Function
depurination
Definitions related to depurination:
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Depurination involves cleavage of the N-glycosidic link between a purine base and the remaining deoxyribose portion of the effected nucleotide in DNA, leading to loss of the purine base while leaving the DNA backbone intact. Depurination must be enzymically repaired to ensure genetic stability; transversion mutations result from purine loss.NCI ThesaurusU.S. National Cancer Institute, 2021
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The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.Gene Ontology DictionaryGene Ontology Consortium, 2021
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