Hormone
desmopressin
Brand Names:
DDAVP; Nocdurna; Noctiva; Stimate
Effect:
Increased Coagulation Factor Concentration; Increased Collecting Duct Water Permeability
May Treat:
Diabetes Insipidus, Neurogenic;
Enuresis;
Hemorrhage;
Thrombocytopenia;
von Willebrand Diseases
More Information:
Definitions related to desmopressin:
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A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.NCI ThesaurusU.S. National Cancer Institute, 2021
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(deamino arginine vasopressin) A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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