Pharmacologic Substance
diaziquone Audio
[ dy-a-zih-kwone ]
Definitions related to diaziquone:
  • A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
    NCI
    U.S. National Cancer Institute, 2021
  • An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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