Pharmacologic Substance
diazooxonorleucine
Subclass of:
Azo Compounds;
Norleucine
Definitions related to diazooxonorleucine:
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An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate.NCI ThesaurusU.S. National Cancer Institute, 2021
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